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Fildena is a medication that contains sildenafil citrate, primarily used to treat erectile dysfunction. As with any medication, it can interact with other drugs. Here are some known drug interactions with Fildena (sildenafil): Nitrates: Using sildenafil with nitrates (e.g., nitroglycerin, isosorbide dinitrate) can lead to a significant drop in blood pressure, which can be dangerous. Alpha-blockers: Medications used for high blood pressure or prostate issues (e.g., doxazosin, terazosin) can also interact with Fildena, leading to low blood pressure. Antibiotics: Certain antibiotics, such as erythromycin and clarithromycin, may increase the concentration of sildenafil in the blood, potentially enhancing its effects and side effects. Antifungals: Drugs like ketoconazole and itraconazole can also increase sildenafil levels in the body. HIV Protease Inhibitors: Medications like ritonavir can elevate sildenafil levels and increase the risk of side effects. Other PDE5 Inhibitors: Combining sildenafil with other medications in the same class (e.g., tadalafil, vardenafil) can increase the risk of side effects. Blood Pressure Medications: Other antihypertensive medications may interact and cause low blood pressure. Grapefruit Juice: Consuming grapefruit or grapefruit juice can increase the levels of sildenafil in the bloodstream. Always consult a healthcare provider before starting or stopping any medication, especially if you're taking Fildena or other medications. They can provide personalized advice based on your health history and current medications.