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Malegra 25 contains Sildenafil Citrate as its active ingredient, belonging to the class of medications known as phosphodiesterase type 5 (PDE5) inhibitors. Here's how Malegra 25 works in the treatment of erectile dysfunction (ED):

Inhibition of PDE5: Malegra 25 works by inhibiting the enzyme PDE5, which is responsible for breaking down cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penis. cGMP is a chemical messenger that promotes relaxation of the smooth muscles and dilation of blood vessels in the penile tissues, allowing for increased blood flow into the penis during sexual stimulation.

Enhanced blood flow: By inhibiting PDE5, Malegra 25mg helps to increase the levels of cGMP, which in turn promotes the relaxation of blood vessels and smooth muscles in the penile region. This enhanced relaxation and vasodilation facilitate a greater influx of blood into the erectile tissues, resulting in a firm and sustainable erection suitable for sexual activity.

Sexual stimulation required: It's important to note that Malegra 25, like other PDE5 inhibitors, does not cause spontaneous erections. Sexual stimulation is still necessary to trigger the release of nitric oxide in the erectile tissue, which initiates the biochemical cascade leading to the production of cGMP and subsequent erection.

Duration of action: Malegra 25 typically starts working within 30 to 60 minutes after ingestion, with its effects lasting for about 4 to 6 hours. The onset and duration of action may vary slightly among individuals based on factors such as metabolism, overall health, and dosage.

Dosage considerations: Malegra 25 is available in different strengths, and the appropriate dosage depends on individual response, tolerability, and the severity of erectile dysfunction. It's important to follow the prescribed dosage and usage instructions provided by a healthcare provider to achieve optimal results and minimize the risk of side effects.