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Tadalista 60 mg contains Tadalafil as its active ingredient, which is a medication used to treat erectile dysfunction (ED) in men. Like other medications, Tadalafil has specific contraindications, or conditions in which its use is not recommended or should be used with caution. Liver or kidney problems are among the medical conditions that may warrant caution or avoidance of Tadalafil use. Here's why: Liver Problems: The liver metabolizes medications, including Tadalafil. If someone has liver problems, their liver may not be able to metabolize the medication effectively, potentially leading to increased levels of Tadalafil in the bloodstream. This could increase the risk of side effects or adverse reactions. Kidney Problems: Tadalista 60 mg is primarily eliminated from the body through the kidneys. If someone has kidney problems, their kidneys may not be able to effectively clear Tadalafil from the body. This can lead to a buildup of the medication in the bloodstream, increasing the risk of side effects. In individuals with liver or kidney problems, the dosage of Tadalafil may need to be adjusted or the medication may need to be avoided altogether. It's crucial for individuals with these conditions to consult their healthcare provider before taking Tadalista 60 mg or any medication containing Tadalafil. A healthcare professional can assess the individual's medical history, overall health, and the potential risks and benefits of using Tadalafil in their specific case. They can also recommend alternative treatments if Tadalafil is not suitable.