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Zhewitra 20 contains Vardenafil, which is a phosphodiesterase type 5 (PDE5) inhibitor. The mechanism by which Zhewitra 20mg helps in achieving and maintaining an erection involves several steps:

Relaxation of Blood Vessels: When a person becomes sexually aroused, nitric oxide (NO) is released in the erectile tissue of the penis. NO then activates an enzyme called guanylate cyclase, leading to an increase in cyclic guanosine monophosphate (cGMP).

Increased cGMP Levels: cGMP is responsible for relaxing the smooth muscles of the penile blood vessels (corpora cavernosa), allowing them to dilate and increase blood flow to the penis.

Enhanced Blood Flow: As the blood vessels in the penis dilate, more blood can flow into the erectile tissue, resulting in an erection. This process is crucial for achieving and maintaining a firm erection during sexual activity.

PDE5 Inhibition: However, another enzyme called phosphodiesterase type 5 (PDE5) breaks down cGMP, reducing its levels and causing the blood vessels to constrict again, leading to the end of the erection.

Prolonged cGMP Activity: Zhewitra 20 inhibits the action of PDE5, allowing cGMP levels to remain elevated. This prolonged activity of cGMP helps maintain the relaxation of penile blood vessels, sustaining the increased blood flow necessary for a longer-lasting erection.

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