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Certainly! Malegra 100 mg contains sildenafil citrate as its active ingredient. Sildenafil citrate is a phosphodiesterase type 5 (PDE5) inhibitor. To understand its mechanism of action, let's break it down: Erection Process: During sexual arousal, the release of nitric oxide (NO) from nerve endings in the penis triggers the production of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penile arteries and corpus cavernosum (erectile tissue). cGMP acts as a signaling molecule, causing the smooth muscles in the arteries of the penis to relax, allowing blood to flow into the erectile tissue and engorge it, resulting in an erection. Role of PDE5: After ejaculation or when sexual stimulation ceases, an enzyme called phosphodiesterase type 5 (PDE5) breaks down cGMP, leading to the relaxation of the penile arteries and the return of blood flow to baseline levels. Malegra 100 Mg action of PDE5 results in the termination of the erection. Mechanism of Sildenafil (Malegra): Sildenafil citrate in Malegra inhibits the action of PDE5 enzyme. By inhibiting PDE5, sildenafil allows cGMP levels to remain elevated for longer periods. This prolonged presence of cGMP enhances the vasodilatory effects of NO, leading to increased blood flow into the penis and sustained erections. Efficacy: It's important to note that sexual stimulation is still required for sildenafil to produce an erection. It does not automatically induce an erection but rather enhances the body's natural response to sexual stimulation. In summary, Malegra 100 mg works by inhibiting the enzyme PDE5, which allows for increased levels of cGMP in the erectile tissue of the penis, leading to improved blood flow and sustained erections during sexual activity.