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What is the mechanism of action of Fildena in the treatment of erectile dysfunction?

What is the mechanism of action of Fildena in the treatment of erectile dysfunction?

by Clifford Fosterr (Posts: 0) » about 12 days ago

Fildena, also known as sildenafil citrate, belongs to a class of medications called phosphodiesterase type 5 (PDE5) inhibitors. Fildena mechanism of action involves enhancing the effects of nitric oxide (NO), a chemical naturally produced in the body that relaxes smooth muscles in the penis and allows for increased blood flow. During sexual stimulation, nitric oxide is released in the erectile tissue of the penis, which activates an enzyme called guanylate cyclase. This enzyme increases levels of cyclic guanosine monophosphate (cGMP), a molecule that relaxes smooth muscles and widens blood vessels in the penis, leading to increased blood flow and erection. However, the enzyme phosphodiesterase type 5 (PDE5) breaks down cGMP, leading to a decrease in its levels and a reduction in the duration and strength of the erection. By inhibiting PDE5, Fildena allows cGMP to accumulate and persist in the penis, promoting sustained blood flow and prolonged erections, thereby helping to treat erectile dysfunction.

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