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Cenforce, like Fildena, is a medication used to treat erectile dysfunction (ED), containing sildenafil citrate. Grapefruit juice can potentially interact with medications, including sildenafil, and alter their effects in the body. Here's why: Inhibition of Enzymes: Grapefruit juice contains compounds that inhibit enzymes in the liver and intestines responsible for breaking down certain medications. In the case of sildenafil, these enzymes, specifically CYP3A4, play a role in metabolizing the drug. Increased Blood Levels: When these enzymes are inhibited by grapefruit juice, the levels of sildenafil in the blood can increase. This elevated concentration can intensify the effects of the medication, potentially leading to an increased risk of side effects such as low blood pressure, dizziness, flushing, headache, and prolonged erection (priapism). Timing Matters: The interaction between grapefruit juice and medications like sildenafil is often dose-dependent and can vary depending on the amount of grapefruit juice consumed and the timing relative to medication intake. Because of the potential interaction between grapefruit juice and sildenafil, it's generally recommended to avoid consuming grapefruit juice while taking Cenforce or any other medication containing sildenafil. Instead, opt for other beverages that won't interfere with the medication's effectiveness or safety. Always consult with your healthcare provider or pharmacist before making any changes to your medication regimen or diet, especially if you have concerns about potential interactions. They can provide personalized advice based on your specific health situation and medication regimen.