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Silditop 100 mg contains sildenafil, which is commonly used to treat erectile dysfunction. When considering drug interactions, it's important to consult with a healthcare professional, as interactions can vary depending on individual health factors and other medications being taken. However, some common drug interactions with sildenafil include: Nitrates: Sildenafil can potentiate the hypotensive effects of nitrates, which are commonly used to treat chest pain (angina). Concomitant use of sildenafil with nitrates can lead to a significant drop in blood pressure, potentially causing dizziness, fainting, or even serious cardiovascular events. Alpha-blockers: These medications are used to treat high blood pressure and benign prostatic hyperplasia (BPH). Concurrent use with sildenafil can also lead to hypotension, particularly when taken together due to their combined effects on blood pressure. Other antihypertensive medications: Silditop 100 Mg used to lower blood pressure, such as beta-blockers or calcium channel blockers, may also have additive effects with sildenafil, potentially leading to symptomatic hypotension. Protease inhibitors: Some medications used to treat HIV/AIDS, such as ritonavir and saquinavir, can inhibit the metabolism of sildenafil, leading to increased sildenafil levels in the body. This can increase the risk of sildenafil-related adverse effects. Other medications: It's important to discuss all medications, including over-the-counter drugs and herbal supplements, with your healthcare provider before starting sildenafil. Some medications may interact with sildenafil by affecting its metabolism or altering its effects on the body. Always consult with your healthcare provider or pharmacist before starting or stopping any medications, especially when taking sildenafil or other drugs for erectile dysfunction. They can provide personalized guidance based on your individual health profile and medication regimen.