Forum > Topic Details


Which neurotransmitter plays a role in Zhewitra 20 Mg mechanism of action?

Which neurotransmitter plays a role in Zhewitra 20 Mg mechanism of action?

by stephen Barkin (Posts: 0) » about 25 days ago

Zhewitra 20 Mg contains vardenafil, which is a medication used to treat erectile dysfunction (ED). Vardenafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which leads to an increase in the levels of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. In the mechanism of action of Zhewitra 20 mg, the neurotransmitter that plays a role is nitric oxide (NO). When sexual stimulation occurs, nitric oxide is released from nerve endings and endothelial cells in the penis. Nitric oxide then activates the enzyme guanylate cyclase, which increases levels of cyclic guanosine monophosphate (cGMP). cGMP relaxes smooth muscle cells within the blood vessels of the penis, allowing them to dilate and increase blood flow, resulting in an erection. So, while vardenafil directly inhibits PDE5, leading to increased cGMP levels, it is the release of nitric oxide that initiates the cascade of events leading to vasodilation and erection.

(0) Answer(s)