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Which drug metabolism pathways are involved in Kamagra Chewable breakdown?

Which drug metabolism pathways are involved in Kamagra Chewable breakdown?

by Robert Tanser (Posts: 0) » about 4 months ago

Kamagra Chewable contains sildenafil citrate as its active ingredient, which is the same active ingredient found in Viagra. Sildenafil is primarily metabolized in the liver by the cytochrome P450 enzyme system, specifically the CYP3A4 (major route) and CYP2C9 (minor route) isoforms. These enzymes catalyze the biotransformation of sildenafil into its major circulating metabolite, N-desmethyl sildenafil, which has similar pharmacological activity to sildenafil but at reduced potency.

After oral administration, sildenafil is rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations within about 30 to 120 minutes. The chewable formulation may result in faster absorption compared to conventional tablets, leading to earlier onset of action.

Once absorbed, sildenafil undergoes extensive first-pass metabolism in the liver before entering systemic circulation. The metabolites are then excreted primarily via the feces (approximately 80%) and to a lesser extent in the urine (approximately 13%).

It's important to note that individual variations in drug metabolism pathways can occur due to factors such as genetic polymorphisms, concomitant medications, liver function, and other physiological factors. Therefore, the metabolism of sildenafil in kamagra chewable may vary among individuals. If you have specific concerns about drug metabolism or interactions, it's advisable to consult with a healthcare professional or pharmacist for personalized advice.



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