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Vidalista, which contains tadalafil, typically begins to take effect within 30 minutes to 2 hours after ingestion. The exact onset time can vary depending on factors such as: Individual metabolism – People with faster metabolisms might experience quicker effects. Food intake – Taking Vidalista with a heavy meal may delay its onset, as food can slow down the absorption process. However, it can still be effective after eating. Dosage – Higher doses may take a bit longer to work, although the general time frame remains the same. For most people, the peak effect occurs around 2 hours after taking the medication. The effects can last for up to 36 hours, which is why tadalafil is often referred to as the "weekend pill."