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What is the mechanism of action of Malegra 25 Mg?

What is the mechanism of action of Malegra 25 Mg?

by Jonis Costtale (Posts: 0) » about 11 days ago

Malegra 25 mg contains sildenafil citrate, which belongs to a class of medications known as phosphodiesterase type 5 (PDE5) inhibitors. Its mechanism of action involves inhibiting the enzyme PDE5 in the smooth muscle cells of the blood vessels in the penis. Here's how it works: Erection Mechanism: During sexual stimulation, nitric oxide (NO) is released in the erectile tissue of the penis, which activates an enzyme called guanylate cyclase. Malegra 25 Mg enzyme increases levels of cyclic guanosine monophosphate (cGMP), which relaxes the smooth muscles and allows blood to flow into the penile tissues, causing an erection. PDE5 Inhibition: PDE5 is responsible for breaking down cGMP. By inhibiting PDE5, sildenafil citrate prolongs the effects of cGMP and enhances erectile function by maintaining increased blood flow to the penis. Result: This mechanism helps men with erectile dysfunction (ED) achieve and maintain an erection suitable for sexual activity. It's essential to note that Malegra 25 mg, like other PDE5 inhibitors, requires sexual stimulation to work effectively and does not cause spontaneous erections. Always follow your healthcare provider's guidance on dosage and usage to ensure safe and effective treatment.

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